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What is Bicalutamide?

Bicalutamide is a non-steroidal antiandrogen used in the treatment of prostate cancer. It binds to androgen receptors and blocks the action of testosterone on cancer cells. It is available as a generic medicine and under brand names like Casodex. In many cases it is prescribed with an LHRH agonist to improve effectiveness.

How it works

It works by blocking androgen signals in the tumor. This slows cancer growth and can help relieve symptoms such as bone pain, urinary problems, and fatigue related to the disease. Bicalutamide is not a chemotherapy drug. It is usually part of a broader treatment plan that may include surgery, radiation, or hormonal therapy.

How to take

The usual dose is 50 mg once daily. Some regimens used in the past used higher doses, like 150 mg daily, but most plans today favor 50 mg. Take with water, with or without food. Do not crush or chew tablets. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double dose.

Potential side effects

Most people tolerate bicalutamide well, but side effects can occur. Common effects include hot flashes, breast swelling or tenderness, fatigue, weight changes, and headaches. Some people notice nausea, diarrhea, constipation, or skin rashes. Gynecomastia and nipple discharge may appear. Contact a clinician if side effects are persistent or bothersome.

Warnings and long-term risks

Very serious liver injury has been reported with this medicine. Seek medical help for symptoms such as dark urine, pale stools, yellowing of skin or eyes, severe fatigue, or upper abdominal pain. The drug can interact with other medicines, including anticoagulants, so tell your doctor about all drugs you take. Regular liver tests may be advised during treatment.

Who should avoid this drug

Women and children should not use bicalutamide. Men with significant liver disease may require dose adjustments or monitoring. Do not use during pregnancy or breastfeeding. People planning to become pregnant should discuss risks with their clinician, as exposure to the drug can affect a fetus.

Storage and practical notes

Store tablets at room temperature in a dry place, away from light. Keep them out of reach of children. Do not use medicine after the expiry date printed on the package. Do not share prescription medicines with others and consult a pharmacist for any storage questions or concerns about safety.

Overall review

Bicalutamide is an important option in prostate cancer care when used with other hormonal therapies. It can slow disease progression and help symptom control. Side effects vary and some are long‑lasting. With proper medical supervision and follow-up, many patients manage treatment effectively and safely.