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Diclofenac

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Arthrotec (Diclofenac) – Patient Information

This information is for patients. It is not a substitute for medical advice. Always read the patient information leaflet and consult a healthcare professional if you have questions.

What is Arthrotec (Diclofenac) for?

Arthrotec is a medicine that combines diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), with misoprostol, a prostaglandin analogue. It is used to relieve pain and reduce inflammation in conditions affecting joints and muscles.

The diclofenac component helps to reduce inflammation, swelling, and pain. The misoprostol component helps protect the stomach lining when an NSAID is needed for a period of time. This combination is designed to lower the risk of stomach ulcers that can be caused by NSAID medicines in people who may need NSAID treatment for several weeks or longer.

In Ireland, Arthrotec may require a prescription depending on local rules. Always check with your doctor or pharmacist about how this medicine fits your treatment plan and what you should do if you miss a dose or have questions about how long to take it.

Arthrotec is intended for adults. It is not recommended for children unless advised by a healthcare professional. Do not use Arthrotec to treat conditions for which a different medicine has been prescribed, unless advised by a clinician.

What conditions does Arthrotec treat?

Arthrotec is used to relieve pain and stiffness in inflammatory conditions of the joints and surrounding tissues, such as osteoarthritis and rheumatoid arthritis. It may also be prescribed for other rheumatic or musculoskeletal problems as determined by a clinician.

As with other NSAIDs, Arthrotec is aimed at reducing symptoms rather than curing the underlying condition. It is typically used for short- or longer-term relief as part of a broader treatment plan, which may include physical therapy and other medications.

Your doctor will decide whether Arthrotec is appropriate for you based on your health history and current medicines. If you have questions about why Arthrotec has been prescribed for you, discuss them with your doctor or pharmacist.

If you experience new or worsening symptoms after starting Arthrotec, contact your clinician. Do not adjust the dose on your own without medical advice.

How Arthrotec works

The diclofenac part of Arthrotec blocks certain enzymes (cyclo-oxygenase enzymes) involved in making prostaglandins, which play a role in inflammation and pain. By reducing these prostaglandins, diclofenac helps lessen pain, swelling and stiffness.

The misoprostol part helps protect the stomach lining by promoting protective factors in the stomach. This is intended to lower the risk of stomach ulcers associated with long-term NSAID use in some people.

Even with the protective aspect of misoprostol, Arthrotec can still cause stomach or intestinal irritation in some people. Avoid taking Arthrotec if you have a known allergy to diclofenac, misoprostol, or prostaglandin medicines. If you have a history of severe stomach ulcers or stomach bleeding, talk to your doctor about whether Arthrotec is appropriate for you.

If you have kidney, liver, or heart problems, or if you are elderly, your risk of side effects may be higher. Always inform your clinician about all medical conditions and medications you take to minimise risk.

How to use Arthrotec

Take Arthrotec exactly as prescribed by your clinician. Do not change the dose or duration without medical advice. The medicine is taken by mouth with a full glass of water, typically with food or shortly after a meal to help protect the stomach.

Swallow the tablet whole. Do not chew, crush, or break the tablet unless your doctor tells you to do so. If you have any difficulty swallowing, speak with your pharmacist about alternatives.

Follow your dosing schedule as instructed by your healthcare professional. If you are unsure about when to take Arthrotec or how long to continue, consult your doctor or pharmacist for guidance. Do not stop the medicine abruptly unless advised, as this may affect symptoms.

If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double up doses to make up for a missed one. If you are unsure what to do after missing a dose, contact your clinician or pharmacist for advice.

Store Arthrotec at room temperature, away from moisture and heat. Keep out of sight and reach of children. Do not use Arthrotec past its expiry date and discard any medicine that is no longer needed in accordance with local guidance.

Who should avoid Arthrotec

Do not use Arthrotec if you have a known allergy to diclofenac, misoprostol, or any other ingredients in the tablet. Also avoid if you have active, serious stomach or intestinal ulcers or a history of bleeding in the digestive tract that is not resolved.

Avoid Arthrotec if you have severe kidney or liver disease, significant heart failure, or uncontrolled high blood pressure. People with a history of asthma or nasal polyps may have an increased risk of an aspirin-like sensitivity to NSAIDs. Discuss these conditions with your clinician before starting Arthrotec.

Pregnant or planning pregnancy: misoprostol can affect the uterus, and NSAIDs may affect a developing fetus. Do not use Arthrotec during pregnancy unless advised by a clinician. If you become pregnant while taking Arthrotec, seek medical advice promptly. Breastfeeding: the medicine passes into breast milk and is generally not recommended during nursing unless a clinician advises otherwise.

People under 18 years of age generally should not take Arthrotec unless specifically prescribed for them by a doctor. Always inform your clinician about all medicines you take and any health conditions you have before starting Arthrotec.

Warnings and precautions

Arthrotec carries a warning for potential stomach or intestinal irritation, ulcers or bleeding, particularly in older adults or when used long-term. Signs such as stomach pain, black or bloody stools, vomiting blood, or severe heartburn should prompt urgent medical attention.

Kidney and liver function can be affected by NSAIDs. Regular monitoring may be required if you have pre-existing kidney or liver conditions, dehydration, or are taking other medications that affect the kidneys or liver. Seek medical advice if you notice unusual tiredness, swelling, or changes in urination.

Heart-related risks, such as high blood pressure, fluid retention, or worsening of heart failure, can occur with NSAIDs in some individuals. If you have a history of heart disease, stroke, or high blood pressure, discuss this with your clinician before starting Arthrotec.

Allergic reactions to NSAIDs or prostaglandin medicines can occur. Symptoms may include hives, swelling of the lips, tongue or face, severe skin rashes, wheezing, or breathing difficulties. If any of these occur, seek urgent medical help.

Avoid combining Arthrotec with other NSAIDs or aspirin unless a clinician specifically advises it. Also be cautious when taking medicines that increase bleeding risk, such as certain anticoagulants, or certain antidepressants. Always inform your clinician about all medicines you take, including over-the-counter products and supplements.

Possible side effects

Most people tolerate Arthrotec well, but side effects can occur. Common side effects include stomach upset, indigestion, heartburn, nausea, vomiting, diarrhoea, or flatulence. Some people may feel dizziness or have a headache.

Less common effects may include rash, itching, or changes in your sense of taste. Some individuals may experience swelling, high blood pressure, or changes in kidney function. If you notice any symptoms of an infection, persistent fever, or unusual tiredness, discuss with a clinician.

Very rare but serious reactions can occur, such as signs of a severe allergic reaction, or symptoms suggesting stomach bleeding or perforation. If you notice unusual stomach pain with blood in vomit or stools, or you have fainting or severe chest pain, seek urgent medical help immediately.

If you are unsure whether a side effect you have is related to Arthrotec, talk to your doctor or pharmacist for guidance. Do not stop the medicine without medical advice unless you are instructed to do so.

Medicines and other interactions

Arthrotec can interact with other medicines. Tell your clinician about all medicines you are taking, including prescription, over-the-counter medicines, vitamins, and herbal products.

Potential interactions include other NSAIDs or aspirin, anticoagulants, corticosteroids, certain blood pressure medicines, antidepressants, and medicines that affect kidney function or electrolyte balance. Some medicines can affect how Arthrotec works, or increase the risk of side effects. Do not start or stop any medicine without discussing with a clinician.

Alcohol can irritate the stomach, especially when taking NSAIDs. Consider limiting alcohol while using Arthrotec and talk to your clinician about any concerns related to your current regimen or health status.

Inform your doctor if you are taking medications for diabetes, gout, epilepsy, or immune-related conditions, as you may need additional monitoring while on Arthrotec.

Pregnancy and breastfeeding

Arthrotec contains misoprostol and diclofenac. Both components can affect pregnancy and fetal development. Do not use Arthrotec if you are pregnant or planning to become pregnant unless a clinician explicitly advises it and closely monitors you.

If you suspect pregnancy while taking Arthrotec, contact your healthcare professional promptly. Do not rely on the medicine to terminate a pregnancy or to protect against pregnancy.

Breastfeeding while taking Arthrotec is generally not advised since diclofenac and misoprostol can pass into breast milk. If you are breastfeeding or planning to breastfeed, talk with your clinician about safe alternatives or timing adjustments.

For both pregnancy and breastfeeding, always discuss your plans with a healthcare professional before starting Arthrotec. If you are trying to conceive or are undergoing fertility treatment, inform your clinician before starting this medicine.

Frequently asked questions

How quickly does Arthrotec work?

Many people notice relief from pain and stiffness within a few hours of taking the medicine, especially after meals. However, the full effect may take longer, and some conditions may respond gradually. If you do not notice improvement after several days, consult your clinician.

Should I take Arthrotec with food?

Taking Arthrotec with food or just after a meal can help protect the stomach and reduce irritation. If you experience stomach upset even with meals, speak to your pharmacist or doctor about how to take it safely.

What should I do if I forget a dose?

If you forget a dose, take it as soon as you remember unless it is near the time for your next dose. Do not double the dose to make up for the missed one. If you are unsure what to do, contact your clinician for guidance.

Can I take Arthrotec with other painkillers?

Do not take other NSAIDs or aspirin together unless advised by a clinician. Some medicines can interact in ways that increase the risk of side effects. Always check with a pharmacist or doctor before combining Arthrotec with other treatments.

Can I drink alcohol while taking Arthrotec?

Alcohol can irritate the stomach, especially when taking NSAIDs. It may increase the risk of stomach upset or ulcers. Discuss your alcohol use with your clinician to understand any specific cautions for you.

Can Arthrotec be used during pregnancy?

Generally, Arthrotec should not be used during pregnancy unless a clinician explicitly advises it. Misoprostol can affect pregnancy, and NSAIDs may affect fetal development. If pregnancy occurs, seek medical advice promptly.

Can I breastfeed while taking Arthrotec?

Breastfeeding while on Arthrotec is usually not advised because both diclofenac and misoprostol can pass into breast milk. Talk with your clinician about safe alternatives if you are breastfeeding or planning to breastfeed.

What should I do if I have stomach upset?

If you experience persistent stomach discomfort, heartburn, or indigestion, speak with your clinician or pharmacist. They may suggest taking the medicine with food, using an antacid as advised, or changing your treatment plan.

When should I contact a doctor or pharmacist?

Seek medical advice if you notice signs of stomach bleeding (black stools, vomiting blood), chest pain, shortness of breath, severe allergic reactions, swelling or sudden weight gain, or changes in urinary habits. Also consult if you experience fever lasting more than a few days, skin rashes, or any new symptoms that worry you.

Is Arthrotec suitable for long-term use?

Long-term NSAID treatment requires regular medical review. Your clinician will assess benefits and risks, including effects on the stomach, kidneys, and heart. Do not extend treatment without a professional check.

What if Arthrotec is not suitable for me?

Your clinician can suggest alternatives such as other analgesics, non-drug therapies, or different medications that do not carry the same risks. Discuss your health history and current medications to find the best option for you.

Sources

For further information, consult the official patient information leaflet provided with Arthrotec, and speak with your doctor or pharmacist. Additional references include national medicines information resources and guidelines used by healthcare professionals in Ireland. If you are unsure about any information, ask your healthcare professional for clarification.

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Airmail

14–21 days. Free from €170.52 .

⚑

Express delivery

5–9 days. €25.58

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