

| Dosage | Package | Price per Dose | Price | |
|---|---|---|---|---|
| 250mg | 360 pills | β¬0.73 | β¬375.41 β¬262.79 Best Price | |
| 250mg | 180 pills | β¬0.87 | β¬224.42 β¬157.09 | |
| 250mg | 90 pills | β¬1.31 | β¬169.33 β¬118.53 | |
| 250mg | 60 pills | β¬1.53 | β¬130.56 β¬91.39 | |
| 250mg | 30 pills | β¬2.04 | β¬87.72 β¬61.40 | |
| 500mg | 360 pills | β¬0.80 | β¬412.14 β¬288.50 Popular | |
| 500mg | 120 pills | β¬1.20 | β¬206.06 β¬144.24 | |
| 500mg | 90 pills | β¬1.46 | β¬187.69 β¬131.39 | |
| 500mg | 60 pills | β¬1.74 | β¬148.93 β¬104.25 | |
| 500mg | 30 pills | β¬2.14 | β¬91.80 β¬64.26 |
Disclaimer: This information is intended to support conversations with a healthcare professional. It does not replace medical advice from a clinician or pharmacist. In Ireland, some medicines may require a prescription depending on local rules.
A historical fact highlights the impact of antibiotics: penicillin-type medicines were among the first effective treatments for many bacterial infections and helped transform modern medicine. This class remains foundational in the management of common bacterial illnesses.
Principen is a brand name for ampicillin, which is the active ingredient. Ampicillin belongs to the beta-lactam family of antibiotics (the beta-lactam ring is a chemical structure essential to its action against bacteria).
The drug is used to treat infections caused by susceptible bacteria. It is considered a broad-spectrum penicillin, meaning it can act against a larger range of bacteria than some other antibiotics within the same class.
In clinical use, Principen may be prescribed for infections of the respiratory tract, urinary tract, skin and soft tissues, and certain other sites where ampicillin is deemed effective. The decision to prescribe depends on the suspected or confirmed organism and local resistance patterns. Always follow the prescribing clinicianβs instructions and refer to the official patient information leaflet for comprehensive guidance.
Infection control relies on using an antibiotic that targets the responsible bacteria. Ampicillin is prescribed when the infection is suspected to be caused by bacteria known to be susceptible to this drug.
Common indications include infections of the upper and lower respiratory tract, such as sinusitis or bronchitis, and infections of the ears, throat, or sinuses. In adults and older children, ampicillin may be used for certain urinary tract infections when indicated by culture results or clinical assessment.
Skin and soft-tissue infections caused by susceptible organisms can also be treated with Principen. A clinician will weigh the benefits against potential risks, taking into account the patientβs history and local resistance patterns.
It is important to note that Principen does not treat viral infections (for example, the common cold or flu). If symptoms are unclear or persist, a healthcare professional should be consulted for assessment and alternative therapy if needed.
Ampicillin acts by interfering with bacterial cell wall synthesis, which is essential for bacteria to maintain their structure. The drug blocks enzymes involved in cross-linking the wallβs building blocks, weakening the wall and allowing the bacteria to rupture and die.
Because humans do not have cell walls, ampicillin selectively targets bacteria while minimizing harm to human cells. This selective action is a hallmark of many antibiotics in the penicillin class.
The action is most effective when bacteria are actively growing and multiplying. Infections caused by bacteria that are not susceptible or that have developed resistance may not respond to treatment, necessitating alternative therapies.
Response to therapy depends on several factors, including the site of infection, bacterial load, immune status, and adherence to the prescribed regimen. If improvement is not seen within a reasonable period, a clinician should be consulted for re-evaluation.
Principen is available in several forms, including oral capsules and oral suspensions. The exact dose and duration are determined by the treating clinician based on age, weight, kidney function, type of infection, and local guidelines.
Many regimens allow for dosing at regular intervals throughout the day. Where advised, the medicine may be taken with or without food. If a specific timing is prescribed, it should be followed to maintain stable levels of the drug in the body.
Oral suspension requires shaking well before measuring the dose to ensure the correct amount is given. A calibrated dosing device or syringe should be used for accuracy, particularly in children. Capsules should be swallowed whole with a full glass of water unless instructed otherwise.
It is important to complete the full course of therapy even if symptoms improve before the planned end date. Stopping early can allow bacteria to survive and potentially develop resistance. If a dose is missed, guidance from a healthcare professional should be sought; do not double up doses unless explicitly advised.
Contraindications are conditions or situations in which Principen should not be used. A penicillin allergy is a common and important contraindication. History of a severe allergic reaction to ampicillin or other penicillins warrants an alternative treatment plan.
Severe renal impairment may require dose adjustments or monitoring, as kidney function influences how the drug is cleared from the body. A clinician will assess kidney function before or during therapy to determine suitability and dosing.
Past occurrences of non-allergic adverse reactions with ampicillin or related drugs should be discussed with a clinician before starting treatment. In some cases, individuals with a history of certain conditions may require close monitoring or an alternative antibiotic.
Check the official leaflet or consult a health professional before starting Principen if any of the above apply. A healthcare professional can provide individualized advice based on medical history and current medications.
Allergies to penicillins have the potential to cause serious reactions. If a rash, itching, swelling, or trouble breathing occurs, seek urgent medical help. Inform healthcare providers about any known penicillin allergy before starting Principen.
Superinfections may occur with antibiotic use. If new symptoms such as watery and persistent diarrhoea develop, especially with fever, contact a clinician promptly as this could indicate a detrimental shift in intestinal flora or other infection.
Gastrointestinal upset is possible. Nausea, vomiting, and stomach pain can occur, but severe symptoms should be discussed with a healthcare professional to rule out other causes.
Kidney function and hydration status influence drug clearance. Dehydration or kidney disease may necessitate dose adjustments or monitoring to avoid adverse effects. Regular review by a clinician is advised for ongoing therapy.
All medicines can interact with others or with certain foods and supplements. A clinician or pharmacist should be informed about all medicines being taken, including over-the-counter products and herbal supplements, to assess potential interactions. If planning long-term use, discuss risks and benefits with a healthcare professional.
Common side effects may include digestive disturbances such as diarrhoea, nausea or vomiting, and skin rashes. Most side effects are mild and transient, but any persistent or worsening symptoms should be reported to a clinician.
Rarer adverse events can involve sensitivity reactions or allergic responses. Signs of a significant reaction include swelling of the face or throat, severe itching, or difficulty breathing; seek urgent medical care if these occur.
Persistent diarrhoea or fever during or after treatment could indicate antibiotic-associated colitis and requires medical attention. Any unusual tiredness, easy bruising, or pale skin should be discussed with a health professional, as they may reflect a blood abnormality or other complication.
Neurologic symptoms such as confusion or seizures are uncommon but possible with high doses or certain patient factors. If these appear, contact a healthcare professional immediately for evaluation.
Certain medicines can interact with ampicillin and affect its effectiveness or safety. Inform a clinician about all prescribed and non-prescribed medicines, including vitamins and herbal products.
Probenecid and some other medicines can alter the levels of ampicillin in the body. A clinician may adjust dosing to avoid undesirable increases or decreases in drug exposure.
Oral contraceptives may have reduced effectiveness when taken with antibiotics, including penicillins, though evidence varies. An additional non-hormonal method of contraception may be advised during treatment and for a short period after completion.
Antacids and iron-containing supplements can interfere with the absorption of some oral antibiotics. If advised to take these agents, space their administration away from Principen by several hours, as directed by a healthcare professional.
Ampicillin is a penicillin antibiotic. The decision to use it during pregnancy requires careful consideration of potential benefits and risks, with administration limited to cases where infection control is necessary and benefits outweigh possible risks to the unborn child.
During breastfeeding, ampicillin passes into breast milk in small amounts. Breastfed infants may be exposed to the medicine. Healthcare professionals will assess the benefit to the mother against potential effects on the infant before continuing treatment.
As with all medicines taken during pregnancy or lactation, consultation with a clinician is essential. If pregnancy is planned or discovered during therapy, a healthcare professional should be informed promptly to determine the appropriate course of action.
Check the official leaflet and discuss with a pharmacist or doctor to ensure safe use in these contexts. Individual risk assessments guide decisions about whether to continue or modify therapy.
In many infections, improvement is seen within a few days if the bacteria are susceptible and the medicine is tolerated. Some infections may take longer to respond, and the full course should be completed even if symptoms improve early. If there is no improvement after a few days, contact a healthcare professional for reassessment.
If a dose is missed, take it as soon as remembered unless it is close to the time of the next dose. Do not double the dose to make up for a missed one unless advised by a clinician. For a modified schedule, consult a healthcare professional for guidance.
No specific interactions between ampicillin and alcohol are widely reported. However, alcohol can worsen some symptoms such as stomach upset or dizziness. Moderation is advised, and if concerns arise, a healthcare professional should be consulted.
The duration is determined by the infection type, severity, and clinical response. The full course should be completed as prescribed to reduce the risk of relapse or resistance. If symptoms persist after finishing the course, seek medical advice.
Contact a clinician if signs of a severe allergic reaction occur, such as facial swelling, difficulty breathing, or a widespread rash. Seek urgent medical help if there is severe diarrhoea, high fever, or signs of a deep infection that is not improving.
Long-term use of any antibiotic requires careful medical supervision. The risk of resistance and disruption of normal bacteria increases with extended courses. Regular review by a healthcare professional is advised to determine the necessity and safety of continued therapy.
Safety depends on the individual clinical scenario. The decision to use ampicillin during pregnancy or breastfeeding is based on the balance of potential risks and benefits and should be guided by a clinician. If pregnancy occurs or is planned, inform the prescribing clinician.
Some antibiotics may interact with certain hormonal contraceptives, potentially reducing their effectiveness. If a concurrent antibiotic course is planned, discuss additional contraception options with a clinician.
Discontinue the medication and seek medical advice promptly if there are signs of a serious reaction. For life-threatening symptoms, seek urgent medical help. A clinician may adjust therapy or substitute another antibiotic if needed.
Ampicillin can be prescribed to children when the infection is susceptible and properly dosed for age and weight. Only a clinician should determine suitability and dosing in pediatric patients, with close monitoring for adverse effects.
Official patient information leaflets accompany the medication and provide detailed instructions, warnings, and storage information. They should be read in conjunction with professional advice.
Consult a pharmacist for medication-specific questions, including how to store the medicine, what to do if a dose is missed, and how to dispose of unused portions safely. Pharmacists can offer guidance on medication interactions and precautions relevant to individual health conditions.
For medical concerns, contact the prescribing clinician who issued the prescription. In Ireland, local health service resources and hospital or community pharmacies can provide access to up-to-date information and support for antibiotic use and stewardship.
When in doubt, always check the official leaflet or seek advice from a healthcare professional to ensure safe and effective use of Principen. Referrals to specialist care may be recommended if certain infections do not respond to treatment or if complications arise.
14β21 days. Free from β¬172.08 .
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β10% on all repeat orders.
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